|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000)|
|Other Names||Tyrosine-protein kinase FRK, 188.8.131.52, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, FRK, PTK5, RAK|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FRK Antibody (clone 1A8H2C12) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery|
|Tissue Location||Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.|
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Provided below are standard protocols that you may find useful for product applications.
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Cance W.G.,et al.Cell Growth Differ. 5:1347-1355(1994).
Lee J.,et al.Gene 138:247-251(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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