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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LAMB1 / Laminin Beta 1 Antibody (clone 2D9G5)   

LAMB1 / Laminin Beta 1 Antibody (clone 2D9G5)

Mouse Monoclonal Antibody

     
  • IHC - LAMB1 / Laminin Beta 1 Antibody (clone 2D9G5) ALS13156
    Anti-LAMB1 antibody IHC of human placenta.
  • IHC - LAMB1 / Laminin Beta 1 Antibody (clone 2D9G5) ALS13156
    Anti-LAMB1 antibody IHC of human thyroid.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P07942
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2D9G5
Calculated MW 198kDa
Dilution IHC-P (1:200), WB (1:500-1:2000),
Additional Information
Gene ID 3912
Other Names Laminin subunit beta-1, Laminin B1 chain, Laminin-1 subunit beta, Laminin-10 subunit beta, Laminin-12 subunit beta, Laminin-2 subunit beta, Laminin-6 subunit beta, Laminin-8 subunit beta, LAMB1
Target/Specificity Human LAMB1
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsLAMB1 / Laminin Beta 1 Antibody (clone 2D9G5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAMB1
Function Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.
Cellular Location Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component
Volume 50 µl
Research Areas
Citations (0)

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Background

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.

References

Vuolteenaho R.,et al.J. Biol. Chem. 265:15611-15616(1990).
Pikkarainen T.,et al.J. Biol. Chem. 262:10454-10462(1987).
Scherer S.W.,et al.Science 300:767-772(2003).
Jaye M.,et al.Am. J. Hum. Genet. 41:605-615(1987).
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).

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$ 395.00
Cat# ALS13156
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