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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TRPM2 Antibody (Internal)   

TRPM2 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - TRPM2 Antibody (Internal) ALS13176
    Anti-TRPM2 antibody IHC of human brain, cortex.
  • IHC - TRPM2 Antibody (Internal) ALS13176
    Anti-TRPM2 antibody IHC of human pancreas.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O94759
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 171kDa
Dilution IHC-P (3.75 µg/ml)
Additional Information
Gene ID 7226
Other Names Transient receptor potential cation channel subfamily M member 2, 3.6.1.13, Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC-2, LTrpC2, Transient receptor potential channel 7, TrpC7, TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Target/Specificity Human TRPM2.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsTRPM2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPM2
Synonyms EREG1, KNP3, LTRPC2, TRPC7
Function Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.
Volume 50 µl
Research Areas
Citations (0)

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Background

Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.

References

Nagamine K.,et al.Genomics 54:124-131(1998).
Wehage E.,et al.J. Biol. Chem. 277:23150-23156(2002).
Zhang W.,et al.J. Biol. Chem. 278:16222-16229(2003).
Uemura T.,et al.Biochem. Biophys. Res. Commun. 328:1232-1243(2005).
Hayes P.D.,et al.Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13176
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