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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   ZBTB7B / HcKrox Antibody (clone 7C12)   

ZBTB7B / HcKrox Antibody (clone 7C12)

Mouse Monoclonal Antibody

     
  • IF - ZBTB7B / HcKrox Antibody (clone 7C12) ALS13187
    Immunofluorescence of HeLa cells using ZBTB7B mouse monoclonal antibody (green).
  • IHC - ZBTB7B / HcKrox Antibody (clone 7C12) ALS13187
    Anti-ZBTB7B antibody IHC of human breast.
  • IHC - ZBTB7B / HcKrox Antibody (clone 7C12) ALS13187
    Anti-ZBTB7B antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O15156
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7C12
Calculated MW 58kDa
Dilution IF (1:200-1:1000), IHC-P (1:200), WB (1:500-1:2000)
Additional Information
Gene ID 51043
Other Names Zinc finger and BTB domain-containing protein 7B, Krueppel-related zinc finger protein cKrox, hcKrox, T-helper-inducing POZ/Krueppel-like factor, Zinc finger and BTB domain-containing protein 15, Zinc finger protein 67 homolog, Zfp-67, Zinc finger protein 857B, Zinc finger protein Th-POK, ZBTB7B, ZBTB15, ZFP67, ZNF857B
Target/Specificity Human ZBTB7B
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsZBTB7B / HcKrox Antibody (clone 7C12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZBTB7B
Synonyms ZBTB15, ZFP67, ZNF857B
Function Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).

References

Widom R.L.,et al.Gene 198:407-420(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13187
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