|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (1:500-1:3000),|
|Other Names||Eukaryotic translation initiation factor 4 gamma 2, eIF-4-gamma 2, eIF-4G 2, eIF4G 2, Death-associated protein 5, DAP-5, p97, EIF4G2 (HGNC:3297)|
|Target/Specificity||Human EIF4G2. Predicted cross-reactivity based on amino acid sequence homology: mouse (100%), rat (100%), rabbit (100%), bovine (100%), zebrafish (82%).|
|Reconstitution & Storage||Aliquot and store at -20°C. Minimize freezing and thawing.|
|Precautions||DAP-5 / EIF4G2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.|
|Tissue Location||Ubiquitously expressed in all adult tissues examined, with high levels in skeletal muscle and heart. Also expressed in fetal brain, lung, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Imataka H.,et al.EMBO J. 16:817-825(1997).
Yamanaka S.,et al.Genes Dev. 11:321-333(1997).
Levy-Strumpf N.,et al.Mol. Cell. Biol. 17:1615-1625(1997).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).
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