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>   home   >   Products   >   Primary Antibodies   >   TIP48 / RUVBL2 Antibody   

TIP48 / RUVBL2 Antibody

Rabbit Polyclonal Antibody

     
  • WB - TIP48 / RUVBL2 Antibody ALS13246
    Sample (30 ug of whole cell lysate).
  • IHC - TIP48 / RUVBL2 Antibody ALS13246
    Anti-RUVBL2 antibody IHC of human skin.
  • IHC - TIP48 / RUVBL2 Antibody ALS13246
    Anti-RUVBL2 antibody IHC of human testis.
  • IHC - TIP48 / RUVBL2 Antibody ALS13246
    Anti-RUVBL2 antibody IHC of human uterus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9Y230
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 51kDa
Dilution IHC-P (10 µg/ml), WB (1:1000-1:10000),
Additional Information
Gene ID 10856
Other Names RuvB-like 2, 3.6.4.12, 48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, ECP-51, INO80 complex subunit J, Repressing pontin 52, Reptin 52, TIP49b, TIP60-associated protein 54-beta, TAP54-beta, RUVBL2, INO80J, TIP48, TIP49B
Target/Specificity Human RUVBL2. Predicted cross-reactivity based on amino acid sequence homology: mouse (99%), rat (99%), bovine (98%), zebrafish (82%).
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsTIP48 / RUVBL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RUVBL2
Synonyms INO80J, TIP48, TIP49B
Function Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes.
Cellular Location Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes
Tissue Location Ubiquitously expressed. Highly expressed in testis and thymus
Volume 50 µl
Citations (0)

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Background

Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

References

Salzer U.,et al.Biochim. Biophys. Acta 1446:365-370(1999).
Kanemaki M.,et al.J. Biol. Chem. 274:22437-22444(1999).
Parfait B.,et al.Ann. Genet. 43:69-74(2000).
Bauer A.,et al.EMBO J. 19:6121-6130(2000).
Wood M.A.,et al.Mol. Cell 5:321-330(2000).

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$ 395.00
Cat# ALS13246
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