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>   home   >   Products   >   Primary Antibodies   >   HMG2 / HMGB2 Antibody (clone 3C7)   

HMG2 / HMGB2 Antibody (clone 3C7)

Mouse Monoclonal Antibody

     
  • WB - HMG2 / HMGB2 Antibody (clone 3C7) ALS13339
    HMGB2 monoclonal antibody (M03), clone 3C7 Western blot of HMGB2 expression in HeLa NE.
  • WB - HMG2 / HMGB2 Antibody (clone 3C7) ALS13339
    Western blot of HMGB2 expression in transfected 293T cell line by HMGB2 monoclonal antibody...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P26583
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3C7
Calculated MW 24kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 3148
Other Names High mobility group protein B2, High mobility group protein 2, HMG-2, HMGB2, HMG2
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsHMG2 / HMGB2 Antibody (clone 3C7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HMGB2
Synonyms HMG2
Function Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
Cellular Location Nucleus Chromosome. Cytoplasm Secreted. Note=In basal state predominantly nuclear.
Tissue Location Expressed in gastric and intestinal tissues (at protein level).
Citations (0)

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Background

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity).

References

Majumdar A.,et al.Nucleic Acids Res. 19:6643-6643(1991).
Shirakawa H.,et al.J. Biol. Chem. 267:6641-6645(1992).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS13339
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