|Application ||IHC-P, E|
|Dilution||ELISA (1:16000), IHC-P (3.75 µg/ml),|
|Other Names||Histone acetyltransferase KAT6A, 22.214.171.124, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3, MYST-3, Monocytic leukemia zinc finger protein, Runt-related transcription factor-binding protein 2, Zinc finger protein 220, KAT6A, MOZ, MYST3, RUNXBP2, ZNF220|
|Target/Specificity||Human MYST3. Reported variants NP_001092882.1, NP_006757.2, NP_001092883.1 represent identical protein.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||MYST3 / MOZ Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MOZ, MYST3, RUNXBP2, ZNF220|
|Function||Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.|
|Cellular Location||Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, PML body. Note=Recruited into PML body after DNA damage|
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Provided below are standard protocols that you may find useful for product applications.
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.
Borrow J.,et al.Nat. Genet. 14:33-41(1996).
Nusbaum C.,et al.Nature 439:331-335(2006).
Hosoda F.,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Carapeti M.,et al.Blood 91:3127-3133(1998).
Chaffanet M.,et al.Genes Chromosomes Cancer 28:138-144(2000).
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