IREB2 / IRP2 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P48200 |
Reactivity | Human, Monkey, Pig |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 105kDa |
Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml) |
Gene ID | 3658 |
---|---|
Other Names | Iron-responsive element-binding protein 2, IRE-BP 2, Iron regulatory protein 2, IRP2, IREB2 |
Target/Specificity | Human IREB2. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | IREB2 / IRP2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IREB2 |
---|---|
Function | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
References
Samaniego F.,et al.J. Biol. Chem. 269:30904-30910(1994).
Ishiwata T.,et al.Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:671-675(2006).
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