TLN1 / Talin Antibody (clone 5C1)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q9Y490 |
Reactivity | Human, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 5C1 |
Calculated MW | 270kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 7094 |
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Other Names | Talin-1, TLN1, KIAA1027, TLN |
Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
Precautions | TLN1 / Talin Antibody (clone 5C1) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TLN1 |
---|---|
Synonyms | KIAA1027, TLN |
Function | High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). Involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). |
Cellular Location | Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface {ECO:0000250|UniProtKB:P26039}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P26039}. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). |
Tissue Location | [Isoform 2]: Expressed at low to non-detectable levels in many tissues but highly expressed in skin and pancreas with other tissues including kidney cortex, endocervix, testis, pituitary, liver, and spleen also showing robust expression |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
References
Mao L.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Ben-Yosef T.,et al.Genomics 62:316-319(1999).
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Humphray S.J.,et al.Nature 429:369-374(2004).
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