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DCYTB / CYBRD1 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q53TN4 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 32kDa |
| Dilution | ELISA (1:16000), IHC-P (2.5 µg/ml), |
| Gene ID | 79901 |
|---|---|
| Other Names | Cytochrome b reductase 1, 1.-.-.-, Duodenal cytochrome b, Ferric-chelate reductase 3, CYBRD1, DCYTB, FRRS3 |
| Target/Specificity | Human CYBRD1 / DCYTB. This antibody is expected to recognise isoform 1 (NP_079119.3) only. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | DCYTB / CYBRD1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CYBRD1 (HGNC:20797) |
|---|---|
| Function | Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:30272000). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:30272000). It is also able to reduce extracellular monodehydro- L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337). May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Localized at the brush border of duodenal cells. |
| Tissue Location | Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.
References
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Zaahl M.G.,et al.Hum. Genet. 115:409-417(2004).
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