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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TRPC4 Antibody (C-Terminus)   

TRPC4 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • WB - TRPC4 Antibody (C-Terminus) ALS13435
    Antibody (0.3 ug/ml) staining of Rat Brain lysate (35 ug protein in RIPA buffer).
  • IHC - TRPC4 Antibody (C-Terminus) ALS13435
    Anti-TRPC4 antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9UBN4
Reactivity Human, Rat, Dog
Host Goat
Clonality Polyclonal
Calculated MW 112kDa
Dilution ELISA (1:32000), IHC-P (4.75 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 7223
Other Names Short transient receptor potential channel 4, TrpC4, Trp-related protein 4, hTrp-4, hTrp4, TRPC4
Target/Specificity Human TRPC4. This antibody is expected to recognise all six reported isoforms (NP_057263.1; NP_003297.1; NP_001129427.1; NP_001129429.1; NP_001129428.1; NP_001129430.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsTRPC4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPC4
Function Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor
Tissue Location Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain
Research Areas
Citations (0)

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Background

Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.

References

McKay R.R.,et al.Biochem. J. 351:735-746(2000).
Mery L.,et al.FEBS Lett. 487:377-383(2001).
Schaefer M.,et al.J. Biol. Chem. 277:3752-3759(2002).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13435
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