|Application ||WB, IHC-P, IF, E|
|Dilution||IF (10 µg/ml), IHC-P (5 µg/ml),|
|Other Names||Glucocorticoid modulatory element-binding protein 1, GMEB-1, DNA-binding protein p96PIF, Parvovirus initiation factor p96, PIF p96, GMEB1|
|Reconstitution & Storage||Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||GMEB1 Antibody (clone 2A8) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.|
|Cellular Location||Nucleus. Cytoplasm. Note=May be also cytoplasmic|
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Provided below are standard protocols that you may find useful for product applications.
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Theriault J.R.,et al.FEBS Lett. 452:170-176(1999).
Christensen J.,et al.Mol. Cell. Biol. 19:7741-7750(1999).
Kaul S.,et al.Mol. Endocrinol. 14:1010-1027(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
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