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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ARH / LDLRAP1 Antibody (clone 4G4-D5)   

ARH / LDLRAP1 Antibody (clone 4G4-D5)

Mouse Monoclonal Antibody

     
  • WB - ARH / LDLRAP1 Antibody (clone 4G4-D5) ALS13485
    LDLRAP1 monoclonal antibody, clone 4G4-D5 Western blot of LDLRAP1 expression in HeLa NE.
  • IF - ARH / LDLRAP1 Antibody (clone 4G4-D5) ALS13485
    Immunofluorescence of monoclonal antibody to LDLRAP1 on HeLa cell (antibody concentration 10 ug/ml).
  • IHC - ARH / LDLRAP1 Antibody (clone 4G4-D5) ALS13485
    Anti-LDLRAP1 antibody IHC of human small intestine, muscularis propria.
  • IHC - ARH / LDLRAP1 Antibody (clone 4G4-D5) ALS13485
    Anti-LDLRAP1 antibody IHC of human vessel.
  • IHC - ARH / LDLRAP1 Antibody (clone 4G4-D5) ALS13485
    Anti-LDLRAP1 antibody IHC of human prostate, smooth muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q5SW96
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4G4-D5
Calculated MW 34kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 26119
Other Names Low density lipoprotein receptor adapter protein 1, Autosomal recessive hypercholesterolemia protein, LDLRAP1, ARH
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsARH / LDLRAP1 Antibody (clone 4G4-D5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LDLRAP1
Synonyms ARH
Function Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.
Cellular Location Cytoplasm.
Tissue Location Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes
Research Areas
Citations (0)

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Background

Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.

References

Garcia C.K.,et al.Science 292:1394-1398(2001).
Wilund K.R.,et al.Hum. Mol. Genet. 11:3019-3030(2002).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Gregory S.G.,et al.Nature 441:315-321(2006).
He G.,et al.J. Biol. Chem. 277:44044-44049(2002).

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$ 450.00
Cat# ALS13485
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