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TWIST2 Antibody (clone 3C8)

Mouse Monoclonal Antibody

     
  • WB - TWIST2 Antibody (clone 3C8) ALS13506
    Western blot of TWIST2 expression in transfected 293T cell line by TWIST2 monoclonal antibody,...
  • IHC - TWIST2 Antibody (clone 3C8) ALS13506
    Anti-TWIST2 antibody IHC of human kidney.
  • IHC - TWIST2 Antibody (clone 3C8) ALS13506
    Anti-TWIST2 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8WVJ9
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3C8
Calculated MW 18kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 117581
Other Names Twist-related protein 2, Class A basic helix-loop-helix protein 39, bHLHa39, Dermis-expressed protein 1, Dermo-1, TWIST2, BHLHA39, DERMO1
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsTWIST2 Antibody (clone 3C8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TWIST2
Synonyms BHLHA39, DERMO1
Function Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:11062344}. Cytoplasm. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues
Tissue Location In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules.
Research Areas
Citations (0)

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Background

Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.

References

Lee M.S.,et al.Bone 27:591-602(2000).
Tukel T.,et al.Am. J. Hum. Genet. 87:289-296(2010).

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$ 450.00
Cat# ALS13506
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