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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Fibulin-3 / EFEMP1 Antibody (C-Terminus)   

Fibulin-3 / EFEMP1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - Fibulin-3 / EFEMP1 Antibody (C-Terminus) ALS13529
    Immunocytochemistry of Fibulin 3 in HeLa cells with Fibulin 3 antibody at 20 ug/ml.
  • IF - Fibulin-3 / EFEMP1 Antibody (C-Terminus) ALS13529
    Immunofluorescence of Fibulin 3 in HeLa cells with Fibulin 3 antibody at 20 ug/ml.
  • IHC - Fibulin-3 / EFEMP1 Antibody (C-Terminus) ALS13529
    Anti-EFEMP1 antibody IHC of human small intestine, capillary.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession Q12805
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 55kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 2202
Other Names EGF-containing fibulin-like extracellular matrix protein 1, Extracellular protein S1-5, Fibrillin-like protein, Fibulin-3, FIBL-3, EFEMP1, FBLN3, FBNL
Target/Specificity Human EFEMP1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsFibulin-3 / EFEMP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EFEMP1
Synonyms FBLN3, FBNL
Function Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
Cellular Location Secreted, extracellular space. Secreted, extracellular space, extracellular matrix Note=Localizes to the lamina propria underneath the olfactory epithelium.
Tissue Location In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina
Research Areas
Citations (0)

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Background

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.

References

Lecka-Czernik B.,et al.Mol. Cell. Biol. 15:120-128(1995).
Ikegawa S.,et al.Genomics 35:590-592(1996).
Giltay R.,et al.Matrix Biol. 18:469-480(1999).
Sauer C.G.,et al.Ophthalmic Genet. 22:27-34(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS13529
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