|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||GRB2-associated and regulator of MAPK protein, GRB2-associated and regulator of MAPK1, GAREM, C18orf11, FAM59A|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||GAREM / FAM59A Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.|
|Tissue Location||Isoform 1 is ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Tashiro K.,et al.J. Biol. Chem. 284:20206-20214(2009).
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