ESX1 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q8N693 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 44kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 80712 |
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Other Names | Homeobox protein ESX1, Extraembryonic, spermatogenesis, homeobox 1, Homeobox protein ESX1-N, Homeobox protein ESX1-C, ESX1, ESX1L, ESX1R |
Target/Specificity | Human ESX1 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | ESX1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ESX1 |
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Synonyms | ESX1L, ESX1R |
Function | May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. |
Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584} Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm |
Tissue Location | Expressed in placenta and testis. Expressed in testicular germ cell tumors. |
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Background
May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
References
Fohn L.E.,et al.Genomics 74:105-108(2001).
Ozawa H.,et al.Oncogene 23:6590-6602(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Yanagihara M.,et al.Oncogene 24:5878-5887(2005).
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