|Application ||WB, IHC-P, IF, ICC, E|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like, APC-like, APC2, APCL|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||APCL / APC2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329).|
|Cellular Location||Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region. Note=Associated with actin filaments (PubMed:11691822, PubMed:25753423). Associated with microtubule network (PubMed:10644998, PubMed:11691822, PubMed:25753423).|
|Tissue Location||Widely expressed (at protein level). Specifically expressed in the CNS.|
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Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.
Nakagawa H.,et al.Cancer Res. 58:5176-5181(1998).
Nakagawa H.,et al.Jpn. J. Cancer Res. 90:982-986(1999).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Carr I.M.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
van Es J.H.,et al.Curr. Biol. 9:105-108(1999).
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