|Dilution||IHC-P (5 µg/ml)|
|Other Names||TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, TAB-3, TGF-beta-activated kinase 1-binding protein 3, TAB3, MAP3K7IP3|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||NAP1 / TAB3 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.|
|Tissue Location||Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.|
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Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
Ishitani T.,et al.EMBO J. 22:6277-6288(2003).
Cheung P.C.,et al.Biochem. J. 378:27-34(2004).
Jin G.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:2028-2033(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
Tian Y.,et al.J. Biol. Chem. 282:16776-16782(2007).
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