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>   home   >   Products   >   Primary Antibodies   >   Developmental Biology   >   FKTN / Fukutin Antibody   

FKTN / Fukutin Antibody

Rabbit Polyclonal Antibody

     
  • IF - FKTN / Fukutin Antibody ALS13654
    Immunofluorescence of methanol-fixed HeLa, using Fukutin antibody at 1:200 dilution.
  • WB - FKTN / Fukutin Antibody ALS13654
    Sample (30 ug of whole cell lysate).
  • IHC - FKTN / Fukutin Antibody ALS13654
    Anti-FKTN / Fukutin antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession O75072
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 54kDa
Dilution ICC (1:100-1:200), IF (1:100-1:200), IHC-P (10 µg/ml), WB (1:500-1:3000) ,
Additional Information
Gene ID 2218
Other Names Fukutin, 2.-.-.-, Fukuyama-type congenital muscular dystrophy protein, FKTN, FCMD
Target/Specificity Human Fukutin. Predicted cross-reactivity based on amino acid sequence homology: mouse (90%), rat (91%).
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsFKTN / Fukutin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FKTN
Synonyms FCMD
Function Glycosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development.
Cellular Location Golgi apparatus membrane; Single-pass type II membrane protein
Tissue Location Widely expressed with highest expression in brain, heart, pancreas and skeletal muscle. Expressed at similar levels in control fetal and adult brain, but is much reduced in Fukuyama-type congenital dystrophy (FCMD) brains. Expressed in migrating neurons, including Cajar-Retzius cells and adult cortical neurons, as well as hippocampal pyramidal cells and cerebellar Purkinje cells. No expression observed in the glia limitans, the subpial astrocytes (which contribute to basement membrane formation) or other glial cells. In the FCMD brain, neurons in regions with no dysplasia show fair expression, whereas transcripts are nearly undetectable in the overmigrated dysplastic region.
Volume 50 µl
Research Areas
Citations (0)

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Background

Glycosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development.

References

Kobayashi K.,et al.Nature 394:388-392(1998).
Kobayashi K.,et al.FEBS Lett. 489:192-196(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Saito K.,et al.Am. J. Med. Genet. 92:184-190(2000).

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$ 395.00
Cat# ALS13654
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