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Anti-RREB1 antibody IHC of human breast.
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Anti-RREB1 antibody IHC of human skin.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q92766 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 181kDa |
| Dilution | ELISA (1:20000), IHC-P (10 µg/ml), |
| Gene ID | 6239 |
|---|---|
| Other Names | Ras-responsive element-binding protein 1, RREB-1, Finger protein in nuclear bodies, Raf-responsive zinc finger protein LZ321, Zinc finger motif enhancer-binding protein 1, Zep-1, RREB1, FINB |
| Target/Specificity | RREB1 Antibody detects endogenous levels of total RREB1 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | RREB1 Antibody (aa560-609) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RREB1 |
|---|---|
| Synonyms | FINB |
| Function | Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). |
| Cellular Location | Nucleus speckle |
| Tissue Location | Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.
References
Fujimoto-Nishiyama A.,et al.Gene 195:267-275(1997).
Date S.,et al.Int. J. Mol. Med. 13:637-642(2004).
Nitz M.D.,et al.Am. J. Pathol. 179:477-486(2011).
Mungall A.J.,et al.Nature 425:805-811(2003).
Thiagalingam A.,et al.Mol. Cell. Biol. 16:5335-5345(1996).
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