|Application ||IHC-P, E|
|Dilution||ELISA (1:20000), IHC-P (10 µg/ml),|
|Other Names||Ras-responsive element-binding protein 1, RREB-1, Finger protein in nuclear bodies, Raf-responsive zinc finger protein LZ321, Zinc finger motif enhancer-binding protein 1, Zep-1, RREB1, FINB|
|Target/Specificity||RREB1 Antibody detects endogenous levels of total RREB1 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||RREB1 Antibody (aa560-609) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.|
|Cellular Location||Nucleus speckle|
|Tissue Location||Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain|
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Provided below are standard protocols that you may find useful for product applications.
Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.
Fujimoto-Nishiyama A.,et al.Gene 195:267-275(1997).
Date S.,et al.Int. J. Mol. Med. 13:637-642(2004).
Nitz M.D.,et al.Am. J. Pathol. 179:477-486(2011).
Mungall A.J.,et al.Nature 425:805-811(2003).
Thiagalingam A.,et al.Mol. Cell. Biol. 16:5335-5345(1996).
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