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AS3MT Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q9HBK9 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 42kDa |
| Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), |
| Gene ID | 57412 |
|---|---|
| Other Names | Arsenite methyltransferase, 2.1.1.137, Methylarsonite methyltransferase, S-adenosyl-L-methionine:arsenic(III) methyltransferase, AS3MT, CYT19 |
| Target/Specificity | Human AS3MT. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | AS3MT Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AS3MT |
|---|---|
| Synonyms | CYT19 |
| Function | Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed:16407288, PubMed:25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8VHT6} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).
References
Wood T.C.,et al.J. Biol. Chem. 281:7364-7373(2006).
Xiao H.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Yu L.,et al.Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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