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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GCC2 Antibody (Internal)   

GCC2 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - GCC2 Antibody (Internal) ALS13702
    Anti-GCC2 antibody IHC of human small intestine.
  • IHC - GCC2 Antibody (Internal) ALS13702
    Anti-GCC2 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q8IWJ2
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 196kDa
Dilution ELISA (1:16000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 9648
Other Names GRIP and coiled-coil domain-containing protein 2, 185 kDa Golgi coiled-coil protein, GCC185, CLL-associated antigen KW-11, CTCL tumor antigen se1-1, Ran-binding protein 2-like 4, RanBP2L4, Renal carcinoma antigen NY-REN-53, GCC2, KIAA0336, RANBP2L4
Target/Specificity Human GCC2. This antibody is expected to recognise both reported isoforms (NP_055450.1and NP_852118.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsGCC2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GCC2
Synonyms KIAA0336, RANBP2L4
Function Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.
Cellular Location Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Background

Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.

References

Nagase T.,et al.DNA Res. 4:141-150(1997).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Krackhardt A.M.,et al.Blood 100:2123-2131(2002).
Eichmueller S.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001).

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$ 395.00
Cat# ALS13702
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