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NANOS3 / NOS-3 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - NANOS3 / NOS-3 Antibody (C-Terminus) ALS13728
    Western blot of Nanos3 in human brain tissue lysate with Nanos3 antibody at 2 ug/ml.
  • IF - NANOS3 / NOS-3 Antibody (C-Terminus) ALS13728
    Immunofluorescence of Nanos3 in Human Brain cells with Nanos3 antibody at 20 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P60323
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 19kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 342977
Other Names Nanos homolog 3, NOS-3, NANOS3, NOS3
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsNANOS3 / NOS-3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NANOS3
Synonyms NOS3
Function Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
Cellular Location Nucleus. Cytoplasm. Cytoplasmic granule {ECO:0000250|UniProtKB:P60324}. Cytoplasm, P-body {ECO:0000250|UniProtKB:P60324}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body {ECO:0000250|UniProtKB:P60324}
Tissue Location Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids
Research Areas
Citations (0)

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Background

Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

References

Grimwood J.,et al.Nature 428:529-535(2004).
Bonaldo M.F.,et al.Genome Res. 6:791-806(1996).
Julaton V.T.,et al.Hum. Mol. Genet. 20:2238-2250(2011).

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$ 395.00
Cat# ALS13728
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