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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   TRPM7 Antibody (aa1817-1863, clone S74-25)   

TRPM7 Antibody (aa1817-1863, clone S74-25)

Mouse Monoclonal Antibody

     
  • IF - TRPM7 Antibody (aa1817-1863, clone S74-25) ALS13767
    TrpM7 (S74-25), Human hippocampus.
  • WB - TRPM7 Antibody (aa1817-1863, clone S74-25) ALS13767
    TrpM7 (S74-25), Human cell line mix.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, IP
Primary Accession Q96QT4
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names S74-25
Calculated MW 213kDa
Dilution ICC (0.1-1 µg/ml), IHC-P (5 µg/ml), IP (1-10 µg/ml), WB (1-10 µg/ml) ,
Additional Information
Gene ID 54822
Other Names Transient receptor potential cation channel subfamily M member 7, 2.7.11.1, Channel-kinase 1, Long transient receptor potential channel 7, LTrpC-7, LTrpC7, TRPM7, CHAK1, LTRPC7
Target/Specificity Detects ~220 kD protein. No cross reactivity with TrpM6.
Reconstitution & Storage Store at -20°C.
PrecautionsTRPM7 Antibody (aa1817-1863, clone S74-25) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPM7
Synonyms CHAK1, LTRPC7
Function Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Cellular Location Membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Background

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

References

Nadler M.J.S.,et al.Nature 411:590-595(2001).
Nadler M.J.S.,et al.Nature 412:660-660(2001).
Ryazanova L.V.,et al.J. Biol. Chem. 279:3708-3716(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmitz C.,et al.Cell 114:191-200(2003).

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$ 395.00
Cat# ALS13767
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