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>   home   >   Products   >   Primary Antibodies   >   KDM4A / JHDM3A / JMJD2A Antibody (Internal)   

KDM4A / JHDM3A / JMJD2A Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • WB - KDM4A / JHDM3A / JMJD2A Antibody (Internal) ALS13770
    Western blot of JMJD2A in rat liver tissue lysate with JMJD2A antibody at (A) 1 and (B) 2 ug/ml.
  • IHC - KDM4A / JHDM3A / JMJD2A Antibody (Internal) ALS13770
    Anti-KDM4A / JMJD2A antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O75164
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 121kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 9682
Other Names Lysine-specific demethylase 4A, 1.14.11.-, JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A, KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
Target/Specificity Human JMJD2A
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsKDM4A / JHDM3A / JMJD2A Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM4A
Synonyms JHDM3A, JMJD2, JMJD2A, KIAA0677
Function Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16024779}
Tissue Location Ubiquitous..
Citations (0)

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Background

Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.

References

Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Gregory S.G.,et al.Nature 441:315-321(2006).
Gray S.G.,et al.J. Biol. Chem. 280:28507-28518(2005).
Zhang D.,et al.Mol. Cell. Biol. 25:6404-6414(2005).
Whetstine J.R.,et al.Cell 125:467-481(2006).

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$ 395.00
Cat# ALS13770
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