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KDM4A / JHDM3A / JMJD2A Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O75164 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 121kDa |
| Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
| Gene ID | 9682 |
|---|---|
| Other Names | Lysine-specific demethylase 4A, 1.14.11.-, JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A, KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677 |
| Target/Specificity | Human JMJD2A |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | KDM4A / JHDM3A / JMJD2A Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KDM4A |
|---|---|
| Synonyms | JHDM3A, JMJD2, JMJD2A, KIAA0677 |
| Function | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys- 4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16024779} |
| Tissue Location | Ubiquitous.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Background
Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
References
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Gregory S.G.,et al.Nature 441:315-321(2006).
Gray S.G.,et al.J. Biol. Chem. 280:28507-28518(2005).
Zhang D.,et al.Mol. Cell. Biol. 25:6404-6414(2005).
Whetstine J.R.,et al.Cell 125:467-481(2006).
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