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>   home   >   Products   >   Primary Antibodies   >   PAGR1 / C16orf53 Antibody (C-Terminus)   

PAGR1 / C16orf53 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - PAGR1 / C16orf53 Antibody (C-Terminus) ALS13779
    Western blot of GAS in EL4 cell lysate in (A) the absence and (B) the presence of blocking...
  • IHC - PAGR1 / C16orf53 Antibody (C-Terminus) ALS13779
    Anti-C16orf53 antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BTK6
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 28kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 79447
Other Names PAXIP1-associated glutamate-rich protein 1, PAXIP1-associated protein 1, PTIP-associated protein 1, PAGR1, C16orf53, PA1
Target/Specificity Human C16orf53
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsPAGR1 / C16orf53 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAGR1
Synonyms C16orf53, PA1
Function Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582).
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed.
Citations (0)

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References

Martin J.,et al.Nature 432:988-994(2004).
Cho Y.-W.,et al.J. Biol. Chem. 282:20395-20406(2007).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Tang L.-Y.,et al.Mol. Cell. Proteomics 6:1952-1967(2007).
Cantin G.T.,et al.J. Proteome Res. 7:1346-1351(2008).

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$ 395.00
Cat# ALS13779
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