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PPAPDC2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - PPAPDC2 Antibody (C-Terminus) ALS13793
    Immunofluorescence of PPAPDC2 in Raji cells with PPAPDC2 antibody at 20 ug/ml.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8IY26
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 32kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 403313
Other Names Presqualene diphosphate phosphatase, 3.1.3.-, Phosphatidic acid phosphatase type 2 domain-containing protein 2, PPAP2 domain-containing protein 2, PPAPDC2
Target/Specificity Human PPAPDC2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsPPAPDC2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLPP6 (HGNC:23682)
Synonyms PPAPDC2
Function Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain.
Research Areas
Citations (0)

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Background

Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Fukunaga K.,et al.J. Biol. Chem. 281:9490-9497(2006).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).

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$ 395.00
Cat# ALS13793
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