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TMEM70 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9BUB7 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 29kDa |
| Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
| Gene ID | 54968 |
|---|---|
| Other Names | Transmembrane protein 70, mitochondrial, TMEM70 |
| Target/Specificity | Human TMEM70 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | TMEM70 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMEM70 (HGNC:26050) |
|---|---|
| Function | Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (PubMed:31652072, PubMed:33753518, PubMed:33359711, PubMed:32275929). Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:33359711, PubMed:18953340, PubMed:20937241, PubMed:31652072). In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (PubMed:32275929). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein. Note=Mostly located within the inner cristae membrane |
| Tissue Location | Lower expressed in the heart than in the liver (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in biogenesis of mitochondrial ATP synthase.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Cizkova A.,et al.Nat. Genet. 40:1288-1290(2008).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Hejzlarova K.,et al.Biochim. Biophys. Acta 1807:144-149(2011).
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