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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   KLHL25 Antibody (Internal)   

KLHL25 Antibody (Internal)

Chicken Polyclonal Antibody

     
  • ICC - KLHL25 Antibody (Internal) ALS13824
    Immunocytochemistry of ENC-2 in Jurkat cells with ENC-2 antibody at 5 ug/ml.
  • IF - KLHL25 Antibody (Internal) ALS13824
    Immunofluorescence of ENC-2 in Jurkat cells with ENC-2 antibody at 20 ug/ml.
  • WB - KLHL25 Antibody (Internal) ALS13824
    Western blot of ENC-2 in Jurkat cell lysate with ENC-2 antibody at 1 ug/ml in (A) the absence...
  • IHC - KLHL25 Antibody (Internal) ALS13824
    Anti-KLHL25 antibody IHC of human spleen.
  • IHC - KLHL25 Antibody (Internal) ALS13824
    Anti-KLHL25 antibody IHC of human thymus.
  • IHC - KLHL25 Antibody (Internal) ALS13824
    Anti-KLHL25 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession Q9H0H3
Reactivity Human
Host Chicken
Clonality Polyclonal
Calculated MW 66kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 64410
Other Names Kelch-like protein 25, Ectoderm-neural cortex protein 2, ENC-2, KLHL25, ENC2
Target/Specificity Human KLHL25
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsKLHL25 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL25
Synonyms ENC2
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Research Areas
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Background

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

References

Corcoran M.M.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 395.00
Cat# ALS13824
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