|Application ||WB, IHC-P, IF, ICC|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Presenilins-associated rhomboid-like protein, mitochondrial, 22.214.171.124, Mitochondrial intramembrane cleaving protease PARL, P-beta, Pbeta, PARL, PSARL|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||PARL / PSARL Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
Pellegrini L.,et al.J. Alzheimers Dis. 3:181-190(2001).
Zhang C.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Sik A.,et al.J. Biol. Chem. 279:15323-15329(2004).
Jeyaraju D.V.,et al.Proc. Natl. Acad. Sci. U.S.A. 103:18562-18567(2006).
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