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PARL / PSARL Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - PARL / PSARL Antibody (N-Terminus) ALS13829
    Immunocytochemistry of PARL in 3T3 cells with PARL antibody at 2.5 ug/ml.
  • IF - PARL / PSARL Antibody (N-Terminus) ALS13829
    Immunofluorescence of PARL in 3T3 cells with PARL antibody at 2.50 ug/ml.
  • IHC - PARL / PSARL Antibody (N-Terminus) ALS13829
    Anti-PARL antibody IHC of human pancreas.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q9H300
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 42kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 55486
Other Names Presenilins-associated rhomboid-like protein, mitochondrial, 3.4.21.105, Mitochondrial intramembrane cleaving protease PARL, P-beta, Pbeta, PARL, PSARL
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsPARL / PSARL Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PARL
Synonyms PSARL
Function Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Background

Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.

References

Pellegrini L.,et al.J. Alzheimers Dis. 3:181-190(2001).
Zhang C.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Sik A.,et al.J. Biol. Chem. 279:15323-15329(2004).
Jeyaraju D.V.,et al.Proc. Natl. Acad. Sci. U.S.A. 103:18562-18567(2006).

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$ 395.00
Cat# ALS13829
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