|Reactivity||Human, Monkey, Sheep, Bovine|
|Dilution||IHC-P (2.5-5 µg/ml)|
|Other Names||Cystic fibrosis transmembrane conductance regulator, CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, 188.8.131.52, cAMP-dependent chloride channel, CFTR, ABCC7|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CFTR Antibody (aa2-14) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|
|Cellular Location||Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Note=In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia.|
|Tissue Location||Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Riordan J.R.,et al.Science 245:1066-1073(1989).
Zielenski J.,et al.Genomics 10:214-228(1991).
Stacy R.,et al.Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.