|Reactivity||Human, Monkey, Sheep, Bovine|
|Dilution||IHC-P (2.5-5 µg/ml)|
|Other Names||Cystic fibrosis transmembrane conductance regulator, CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, 220.127.116.11, cAMP-dependent chloride channel, CFTR, ABCC7|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CFTR Antibody (aa2-14) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|
|Cellular Location||Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Note=In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia.|
|Tissue Location||Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level)|
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Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
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Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
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