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TINF2 Antibody (aa341-354)

Goat Polyclonal Antibody

     
  • IHC - TINF2 Antibody (aa341-354) ALS13851
    Anti-TINF2 antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9BSI4
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 50kDa
Dilution IHC-P (3.75-7.5 µg/ml)
Additional Information
Gene ID 26277
Other Names TERF1-interacting nuclear factor 2, TRF1-interacting nuclear protein 2, TINF2, TIN2
Target/Specificity Human TINF2.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsTINF2 Antibody (aa341-354) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TINF2
Synonyms TIN2
Function Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
Cellular Location Nucleus. Chromosome, telomere Note=Associated with telomeres
Tissue Location Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
Citations (0)

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Background

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.

References

Kim S.-H.,et al.Nat. Genet. 23:405-412(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kaminker P.G.,et al.Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
Loayza D.,et al.Nature 423:1013-1018(2003).
Ye J.Z.-S.,et al.Genes Dev. 18:1649-1654(2004).

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$ 395.00
Cat# ALS13851
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