TINF2 Antibody (aa341-354)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | Q9BSI4 |
Reactivity | Human, Monkey |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 50kDa |
Dilution | IHC-P (3.75-7.5 µg/ml) |
Gene ID | 26277 |
---|---|
Other Names | TERF1-interacting nuclear factor 2, TRF1-interacting nuclear protein 2, TINF2, TIN2 |
Target/Specificity | Human TINF2. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | TINF2 Antibody (aa341-354) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TINF2 |
---|---|
Synonyms | TIN2 |
Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. |
Cellular Location | Nucleus. Chromosome, telomere. Note=Associated with telomeres |
Tissue Location | Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas |
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Background
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
References
Kim S.-H.,et al.Nat. Genet. 23:405-412(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kaminker P.G.,et al.Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
Loayza D.,et al.Nature 423:1013-1018(2003).
Ye J.Z.-S.,et al.Genes Dev. 18:1649-1654(2004).
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