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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TAB2 Antibody (aa161-173)   

TAB2 Antibody (aa161-173)

Goat Polyclonal Antibody

     
  • IHC - TAB2 Antibody (aa161-173) ALS13865
    Anti-TAB2 antibody IHC of human colon.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9NYJ8
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 76kDa
Dilution IHC-P (3.75-7.5 µg/ml)
Additional Information
Gene ID 23118
Other Names TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TAB-2, TGF-beta-activated kinase 1-binding protein 2, TAB2, KIAA0733, MAP3K7IP2
Target/Specificity Human TAB2.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsTAB2 Antibody (aa161-173) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAB2
Synonyms KIAA0733, MAP3K7IP2
Function Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
Cellular Location Membrane; Peripheral membrane protein Cytoplasm, cytosol. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol
Tissue Location Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
Research Areas
Citations (0)

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Background

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.

References

Takaesu G.,et al.Mol. Cell 5:649-658(2000).
Nagase T.,et al.DNA Res. 5:277-286(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13865
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