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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MMP13 Antibody   

MMP13 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - MMP13 Antibody ALS13890
    Anti-MMP13 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P45452
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 54kDa
Dilution IHC-P (20 µg/ml), WB (1:25-1:50),
Additional Information
Gene ID 4322
Other Names Collagenase 3, 3.4.24.-, Matrix metalloproteinase-13, MMP-13, MMP13
Reconstitution & Storage Stable for 24 months when stored at 2-8°C.
PrecautionsMMP13 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP13
Function Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
Cellular Location Secreted, extracellular space, extracellular matrix. Secreted
Tissue Location Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue.
Volume 125 µl
Research Areas
Citations (0)

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Background

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

References

Freije J.M.P.,et al.J. Biol. Chem. 269:16766-16773(1994).
Willmroth F.,et al.Immunobiology 198:375-384(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Knaeuper V.,et al.J. Biol. Chem. 271:1544-1550(1996).
Knaeuper V.,et al.J. Biol. Chem. 271:17124-17131(1996).

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$ 395.00
Cat# ALS13890
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