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IL16 Antibody (clone G11/II)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q14005 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | G11/II |
| Calculated MW | 142kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 3603 |
|---|---|
| Other Names | Pro-interleukin-16, Interleukin-16, IL-16, Lymphocyte chemoattractant factor, LCF, IL16 |
| Target/Specificity | G11/II detects LCF, a homotetrameric glycoprotein of 56kDa molecular weight that is composed of four noncovalently linked peptides of 14 kDa. Specificity: Human: LCF (IL-16). Other species: not tested. |
| Reconstitution & Storage | Aliquot and store at -20°C. Minimize freezing and thawing. |
| Precautions | IL16 Antibody (clone G11/II) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL16 |
|---|---|
| Function | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA- binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Cellular Location | [Interleukin-16]: Secreted. [Isoform 3]: Cytoplasm. Nucleus. |
| Tissue Location | [Isoform 3]: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation |
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Provided below are standard protocols that you may find useful for product applications.
Background
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
References
Bannert N.,et al.J. Biol. Chem. 278:42190-42199(2003).
Wang P.,et al.BMC Genomics 10:518-518(2009).
Kornfeld H.,et al.Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
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