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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   IL16 Antibody (clone G11/II)   

IL16 Antibody (clone G11/II)

Mouse Monoclonal Antibody

     
  • IHC - IL16 Antibody (clone G11/II) ALS13931
    Anti-IL-16 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q14005
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names G11/II
Calculated MW 142kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 3603
Other Names Pro-interleukin-16, Interleukin-16, IL-16, Lymphocyte chemoattractant factor, LCF, IL16
Target/Specificity G11/II detects LCF, a homotetrameric glycoprotein of 56kDa molecular weight that is composed of four noncovalently linked peptides of 14 kDa. Specificity: Human: LCF (IL-16). Other species: not tested.
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsIL16 Antibody (clone G11/II) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL16
Function Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Cellular Location Interleukin-16: Secreted. Isoform 3: Cytoplasm. Nucleus.
Tissue Location Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation
Research Areas
Citations (0)

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Background

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

References

Bannert N.,et al.J. Biol. Chem. 278:42190-42199(2003).
Wang P.,et al.BMC Genomics 10:518-518(2009).
Kornfeld H.,et al.Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).

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$ 395.00
Cat# ALS13931
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