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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CDKN2A / p16INK4a Antibody (clone 1E12E10)   

CDKN2A / p16INK4a Antibody (clone 1E12E10)

Mouse Monoclonal Antibody

     
  • IHC - CDKN2A / p16INK4a Antibody (clone 1E12E10) ALS13932
    Anti-p16INK4A antibody IHC of human colon, crypt.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P42771
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names 1E12E10
Calculated MW 17kDa
Dilution ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 1029
Other Names Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, Cyclin-dependent kinase 4 inhibitor A, CDK4I, Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A, CDKN2A, CDKN2, MTS1
Target/Specificity Targets P16. Shows reactivity with Human, Mouse, and Rat samples.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsCDKN2A / p16INK4a Antibody (clone 1E12E10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDKN2A (HGNC:1787)
Synonyms CDKN2, MTS1
Function Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific
Research Areas
Citations (0)

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Background

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

References

Serrano M.,et al.Nature 366:704-707(1993).
Robertson K.D.,et al.Oncogene 18:3810-3820(1999).
Kitagawa Y.,et al.J. Biol. Chem. 277:46289-46297(2002).
Lin Y.C.,et al.Oncogene 26:7017-7027(2007).
Humphray S.J.,et al.Nature 429:369-374(2004).

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$ 395.00
Cat# ALS13932
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