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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   SIP1 Antibody (C-Terminus)   

SIP1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - SIP1 Antibody (C-Terminus) ALS13956
    Immunocytochemistry of SIP1 in HeLa cells with SIP1 antibody at 4 ug/ml.
  • IF - SIP1 Antibody (C-Terminus) ALS13956
    Immunofluorescence of SIP1 in HeLa cells with SIP1 antibody at 20 ug/ml.
  • WB - SIP1 Antibody (C-Terminus) ALS13956
    Western blot analysis of SIP1 in HeLa cell lysate with SIP1 antibody at (A) 0.5 and (B) 1ug/ml.
  • IHC - SIP1 Antibody (C-Terminus) ALS13956
    Anti-SIP1 antibody IHC of human colon, nerve.
  • IHC - SIP1 Antibody (C-Terminus) ALS13956
    Anti-SIP1 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession O14893
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 32kDa
Dilution ICC (4 µg/ml), IHC-P (5 µg/ml), WB (0.5-1 µg/ml)
Additional Information
Gene ID 8487
Other Names Gem-associated protein 2, Gemin-2, Component of gems 2, Survival of motor neuron protein-interacting protein 1, SMN-interacting protein 1, GEMIN2, SIP1
Target/Specificity Human SIP1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsSIP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GEMIN2
Synonyms SIP1
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Cellular Location Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm
Volume 250 µl
Research Areas
Citations (0)

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Background

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

References

Liu Q.,et al.Cell 90:1013-1021(1997).
Aerbajinai W.,et al.Int. J. Biochem. Cell Biol. 34:699-707(2002).
Helmken C.,et al.Eur. J. Hum. Genet. 8:493-499(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gubitz A.K.,et al.J. Biol. Chem. 277:5631-5636(2002).

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$ 395.00
Cat# ALS13956
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