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NOD8 / NLRP10 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q86W26 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 75kDa |
| Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
| Gene ID | 338322 |
|---|---|
| Other Names | NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8, NLRP10, NALP10, NOD8, PYNOD |
| Target/Specificity | Human NLRP10 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | NOD8 / NLRP10 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NLRP10 |
|---|---|
| Synonyms | NALP10, NOD8, PYNOD |
| Function | Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti- inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819). |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection |
| Tissue Location | Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level) (PubMed:22672233). Widely expressed with highest levels in heart, brain and skeletal muscle (PubMed:15096476). Also expressed in liver, colon, dermis and epidermis (PubMed:15096476). Little expression detected in myeloid cells or peripheral blood mononuclear cells (PubMed:15096476). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.
References
Tschopp J.,et al.Nat. Rev. Mol. Cell Biol. 4:95-104(2003).
Wang Y.,et al.Int. Immunol. 16:777-786(2004).
Inohara N.,et al.Nat. Rev. Immunol. 3:371-382(2003).
Imamura R.,et al.J. Immunol. 184:5874-5884(2010).
Lautz K.,et al.Cell. Microbiol. 14:1568-1583(2012).
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