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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   NOD8 / NLRP10 Antibody (N-Terminus)   

NOD8 / NLRP10 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - NOD8 / NLRP10 Antibody (N-Terminus) ALS13988
    Immunofluorescence of NALP10 in human brain tissue with NALP10 antibody at 20 ug/ml.
  • WB - NOD8 / NLRP10 Antibody (N-Terminus) ALS13988
    Western blot analysis of NALP10 in human brain tissue lysate with NALP10 antibody at 1 ug/ml.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q86W26
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 75kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 338322
Other Names NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8, NLRP10, NALP10, NOD8, PYNOD
Target/Specificity Human NLRP10
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsNOD8 / NLRP10 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP10
Synonyms NALP10, NOD8, PYNOD
Function Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.
Cellular Location Cytoplasm. Cell membrane. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection
Tissue Location Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis. Little expression detected in myeloid cells or peripheral blood mononuclear cells.
Research Areas
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Background

Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.

References

Tschopp J.,et al.Nat. Rev. Mol. Cell Biol. 4:95-104(2003).
Wang Y.,et al.Int. Immunol. 16:777-786(2004).
Inohara N.,et al.Nat. Rev. Immunol. 3:371-382(2003).
Imamura R.,et al.J. Immunol. 184:5874-5884(2010).
Lautz K.,et al.Cell. Microbiol. 14:1568-1583(2012).

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$ 395.00
Cat# ALS13988
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