|Application ||WB, IHC-P, IF, ICC, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Pappalysin-2, 3.4.24.-, Pregnancy-associated plasma protein A2, PAPP-A2, Pregnancy-associated plasma protein E1, PAPP-E, PAPPA2, PLAC3|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||PAPPA2 / Pappalysin 2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.|
|Tissue Location||Expressed abundantly in placenta, and non- pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.
Overgaard M.T.,et al.J. Biol. Chem. 276:21849-21853(2001).
Page N.M.,et al.Placenta 22:681-687(2001).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Farr M.,et al.Biochim. Biophys. Acta 1493:356-362(2000).
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