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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FBXO11 Antibody (clone 4C12)   

FBXO11 Antibody (clone 4C12)

Mouse Monoclonal Antibody

     
  • IF - FBXO11 Antibody (clone 4C12) ALS14105
    Immunofluorescence of monoclonal antibody to FBXO11 on HeLa cell. [antibody concentration 10 ug/ml].
  • IHC - FBXO11 Antibody (clone 4C12) ALS14105
    Anti-FBXO11 antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q86XK2
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4C12
Calculated MW 104kDa
Dilution IF (10 µg/ml), IHC-P (2.5 µg/ml),
Additional Information
Gene ID 80204
Other Names F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11, FBX11, PRMT9, VIT1
Target/Specificity Human FBXO11
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsFBXO11 Antibody (clone 4C12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO11
Synonyms FBX11, PRMT9, VIT1
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF- beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Cellular Location Nucleus. Chromosome.
Tissue Location Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
Research Areas
Citations (0)

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Background

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF- beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.

References

Abida W.M.,et al.J. Biol. Chem. 282:1797-1804(2007).
Mao Y.-M.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 450.00
Cat# ALS14105
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