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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CIITA Antibody (N-Terminus)   

CIITA Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - CIITA Antibody (N-Terminus) ALS14120
    Immunofluorescence of CIITA in human brain tissue with CIITA antibody at 20 ug/ml.
  • WB - CIITA Antibody (N-Terminus) ALS14120
    Western blot analysis of CIITA in mouse brain tissue lysate with CIITA antibody at 1 ug/ml.
  • IHC - CIITA Antibody (N-Terminus) ALS14120
    Anti-CIITA antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P33076
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 124kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 4261
Other Names MHC class II transactivator, CIITA, 2.3.1.-, 2.7.11.1, CIITA, MHC2TA
Target/Specificity Human CIITA
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCIITA Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CIITA
Synonyms MHC2TA
Function Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).
Cellular Location Nucleus. Nucleus, PML body. Note=Recruited to PML body by PML
Research Areas
Citations (0)

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Background

Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).

References

Steimle V.,et al.Cell 75:135-146(1993).
Riley J.L.,et al.Immunity 2:533-543(1995).
Quinn G.,et al.Eur. J. Immunogenet. 30:259-270(2003).
Day N.E.,et al.Leuk. Res. 27:1027-1038(2003).
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14120
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