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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ETK / BMX Antibody (aa11-60)   

ETK / BMX Antibody (aa11-60)

Rabbit Polyclonal Antibody

     
  • IF - ETK / BMX Antibody (aa11-60) ALS14201
    Immunofluorescence of A549 cells, using BMX Antibody.
  • WB - ETK / BMX Antibody (aa11-60) ALS14201
    Western blot of extracts from COS7 cells, using BMX Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P51813
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 78kDa
Dilution ELISA (1:20000), IF (1:100-1:500), IHC-P (20 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 660
Other Names Cytoplasmic tyrosine-protein kinase BMX, 2.7.10.2, Bone marrow tyrosine kinase gene in chromosome X protein, Epithelial and endothelial tyrosine kinase, ETK, NTK38, BMX
Target/Specificity BMX Antibody detects endogenous levels of total BMX protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsETK / BMX Antibody (aa11-60) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMX
Function Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
Cellular Location Cytoplasm. Note=Localizes to the edges of spreading cells when complexed with BCAR1
Tissue Location Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines
Volume 50 µl
Research Areas
Citations (0)

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Background

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.

References

Tamagnone L.,et al.Oncogene 9:3683-3688(1994).
Qiu Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:3644-3649(1998).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Nore B.F.,et al.Biochim. Biophys. Acta 1645:123-132(2003).

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$ 395.00
Cat# ALS14201
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