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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   TPX2 Antibody (aa301-350)   

TPX2 Antibody (aa301-350)

Rabbit Polyclonal Antibody

     
  • WB - TPX2 Antibody (aa301-350) ALS14206
    Western blot of extracts from Jurkat cells, using TPX2 Antibody.
  • IHC - TPX2 Antibody (aa301-350) ALS14206
    Anti-TPX2 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9ULW0
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 86kDa
Dilution ELISA (1:1000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 22974
Other Names Targeting protein for Xklp2, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Hepatocellular carcinoma-associated antigen 519, Hepatocellular carcinoma-associated antigen 90, Protein fls353, Restricted expression proliferation-associated protein 100, p100, TPX2, C20orf1, C20orf2, DIL2, HCA519
Target/Specificity TPX2 Antibody detects endogenous levels of total TPX2 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsTPX2 Antibody (aa301-350) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TPX2
Synonyms C20orf1, C20orf2, DIL2, HCA519
Function Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.
Cellular Location Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules
Tissue Location Expressed in lung carcinoma cell lines but not in normal lung tissues
Research Areas
Citations (0)

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Background

Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.

References

Manda R.,et al.Genomics 61:5-14(1999).
Zhang Y.,et al.Cytogenet. Cell Genet. 84:182-183(1999).
Nezu J.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Wang Y.,et al.J. Immunol. 169:1102-1109(2002).
Deloukas P.,et al.Nature 414:865-871(2001).

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$ 395.00
Cat# ALS14206
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