|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:64000), IHC-P (6.12 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Docking protein 3, Downstream of tyrosine kinase 3, DOK3|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||DOK3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed in spleen.|
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Provided below are standard protocols that you may find useful for product applications.
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Favre C.,et al.Genes Immun. 4:40-45(2003).
Zahedi R.P.,et al.J. Proteome Res. 7:526-534(2008).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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