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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DOK3 Antibody (C-Terminus)   

DOK3 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • WB - DOK3 Antibody (C-Terminus) ALS14221
    Antibody staining (0.1 ug/ml) of Human PBMC lysate (RIPA buffer, 35 ug total protein per lane).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q7L591
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 53kDa
Dilution ELISA (1:64000), IHC-P (6.12 µg/ml), WB (0.1-0.3 µg/ml)
Additional Information
Gene ID 79930
Other Names Docking protein 3, Downstream of tyrosine kinase 3, DOK3
Target/Specificity Human DOK3.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDOK3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOK3
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Expressed in spleen.
Research Areas
Citations (0)

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Background

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Favre C.,et al.Genes Immun. 4:40-45(2003).
Zahedi R.P.,et al.J. Proteome Res. 7:526-534(2008).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).

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$ 395.00
Cat# ALS14221
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