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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IRS1 Antibody (aa289-338)   

IRS1 Antibody (aa289-338)

Rabbit Polyclonal Antibody

     
  • IF - IRS1 Antibody (aa289-338) ALS14227
    Immunofluorescence of COS7 cells, using IRS-1 (Ab-323) Antibody.
  • IHC - IRS1 Antibody (aa289-338) ALS14227
    Anti-IRS1 antibody IHC of human adrenal medulla.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, E
Primary Accession P35568
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 132kDa
Dilution ELISA (1:1000), IF (1:100-1:500), IHC-P (10 µg/ml)
Additional Information
Gene ID 3667
Other Names Insulin receptor substrate 1, IRS-1, IRS1
Target/Specificity IRS1 Antibody detects endogenous levels of total IRS1 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsIRS1 Antibody (aa289-338) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRS1
Function May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Volume 50 µl
Research Areas
Citations (0)

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Background

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

References

Araki E.,et al.Diabetes 42:1041-1054(1993).
Nishiyama M.,et al.Biochem. Biophys. Res. Commun. 183:280-285(1992).
Smith L.K.,et al.Biochem. Biophys. Res. Commun. 196:767-772(1993).
Craparo A.,et al.J. Biol. Chem. 270:15639-15643(1995).
He W.,et al.J. Biol. Chem. 270:23258-23262(1995).

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$ 395.00
Cat# ALS14227
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