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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CFLAR / FLIP Antibody (clone 2F12)   

CFLAR / FLIP Antibody (clone 2F12)

Mouse Monoclonal Antibody

     
  • WB - CFLAR / FLIP Antibody (clone 2F12) ALS14232
    CFLAR monoclonal antibody, clone 2F12 Western blot of CFLAR expression in IMR-32.
  • IF - CFLAR / FLIP Antibody (clone 2F12) ALS14232
    Immunofluorescence of monoclonal antibody to CFLAR on HeLa cell. [antibody concentration 10 ug/ml]
  • IHC - CFLAR / FLIP Antibody (clone 2F12) ALS14232
    Anti-CFLAR / FLIP antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O15519
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2F12
Calculated MW 55kDa
Dilution IF (10 µg/ml), IHC-P (10 µg/ml),
Additional Information
Gene ID 8837
Other Names CASP8 and FADD-like apoptosis regulator, Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, Cellular FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, CASP8 and FADD-like apoptosis regulator subunit p43, CASP8 and FADD-like apoptosis regulator subunit p12, CFLAR, CASH, CASP8AP1, CLARP, MRIT
Target/Specificity Human CFLAR
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCFLAR / FLIP Antibody (clone 2F12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFLAR
Synonyms CASH, CASP8AP1, CLARP, MRIT
Function Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Tissue Location Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle
Research Areas
Citations (0)

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Background

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

References

Shu H.-B.,et al.Immunity 6:751-763(1997).
Han D.K.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11333-11338(1997).
Irmler M.,et al.Nature 388:190-195(1997).
Srinivasula S.M.,et al.J. Biol. Chem. 272:18542-18545(1997).
Hu S.,et al.J. Biol. Chem. 272:17255-17257(1997).

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$ 450.00
Cat# ALS14232
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