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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   EBI3 Antibody (clone DNT27)   

EBI3 Antibody (clone DNT27)

Rat Monoclonal Antibody

     
  • WB - EBI3 Antibody (clone DNT27) ALS14238
    Recombinant mouse EBI3/p28 (covalently linked IL-27) protein (lane 1) and mouse bone...
  • IHC - EBI3 Antibody (clone DNT27) ALS14238
    Anti-EBI3 antibody IHC of human lymphoid-dendritic cells.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q14213
Reactivity Human, Mouse
Host Rat
Clonality Monoclonal
Clone Names DNT27
Calculated MW 25kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 10148
Other Names Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, EBI3, IL27B
Reconstitution & Storage Store at 4°C, avoid repeated freeze thaw cycles.
PrecautionsEBI3 Antibody (clone DNT27) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EBI3
Synonyms IL27B
Function Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Cellular Location Secreted.
Volume 50 µl
Research Areas
Citations (0)

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Background

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

References

Devergne O.,et al.J. Virol. 70:1143-1153(1996).
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Devergne O.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:12041-12046(1997).

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$ 395.00
Cat# ALS14238
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