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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VCL / Vinculin Antibody (aa786-835)   

VCL / Vinculin Antibody (aa786-835)

Rabbit Polyclonal Antibody

     
  • IF - VCL / Vinculin Antibody (aa786-835) ALS14239
    Immunofluorescence of A549 cells, using Vinculin Antibody.
  • WB - VCL / Vinculin Antibody (aa786-835) ALS14239
    Western blot of extracts from HeLa cells, treated with forskolin 40 nM 30 minutes, using...
  • IHC - VCL / Vinculin Antibody (aa786-835) ALS14239
    Anti-Vinculin antibody IHC of human heart.
  • IHC - VCL / Vinculin Antibody (aa786-835) ALS14239
    Anti-Vinculin antibody IHC of human kidney, tubules.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P18206
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 124kDa
Dilution ELISA (1:10000), IF (1:100-1:500), IHC-P (10 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 7414
Other Names Vinculin, Metavinculin, MV, VCL
Target/Specificity Vinculin (Ab-821) Antibody detects endogenous levels of total Vinculin protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsVCL / Vinculin Antibody (aa786-835) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VCL
Function Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Cellular Location Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II- dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity) Colocalizes with LIMD1 in the focal adhesions.
Tissue Location Metavinculin is muscle-specific.
Volume 50 µl
Research Areas
Citations (0)

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Background

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

References

Weller P.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:5667-5671(1990).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Deloukas P.,et al.Nature 429:375-381(2004).
Moiseyeva E.P.,et al.J. Biol. Chem. 268:4318-4325(1993).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.

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$ 395.00
Cat# ALS14239
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